Davao del Sur State College, located in Digos City, Davao del Sur, was a satellite campus of Southern Philippines Agribusiness and Marine and Aquatic School of Technology (SPAMAST) whose main campus is located in Malita, Davao Occidental.

On October 3, 2016, Rep. Lorna P. Bautista-Bandigan filed House Bill 3927 entitled: "An Act Removing the Digos City Campus as Part of the Southern Philippines Agri-business and Marine and Aquatic School of Technology(SPAMAST), Appropriating Funds Therefor, and for other Purposes".

Rep. Mercedes "Didi" C. Cagas filed House Bill 5243 (with Rep. Jose Antonio Sy-Alvarado as co-author). The bill was titled: "An Act Converting the Southern Philippines Agri-business and Marine and Aquatic School of Technology (SPAMAST) Davao del Sur Campuses Into a State College to be Known as Davao del Sur State College and Appropriating Funds Therefore." The bill was filed on March 14, 2017.

Rep. Cagas and Rep. Bandigan agreed to consolidate their respective bills, which gave rise to House Bill 6715 An Act Separating the Southern Philippines Agri-business Marine and Aquatic School of Technology (SPAMAST)-Digos City Campus in the City of Digos, Davao del Sur from the SPAMAST in the Municipality of Malita, Davao Occidental, and Converting it into A State College to be known as the Davao del Sur State College, And Appropriating Funds Therefor". The bill was approved by the House of Representatives on December 11, 2017.

On August 28, 2018, The Senate Accepted the request by the Lower House for a conference on House Bill 6715. The Senate approved the conference committee report on November 27, 2018. It was also approved by Congress on the following day. They agreed on the final title-"An Act Separating The Southern Philippines Agri-business Marine and Aquatic School of Technology(SPAMAST)-Digos City Campus in the City of Digos, Davao del Sur from the SPAMAST in the Municipality of Malita, Davao Occidental, And Converting it into A State College to be known as the Davao del Sur State College and Appropriating Funds Therefor".

The bill was signed into law by President Rodrigo R. Duterte on February 21, 2019. It is now known as Republic Act 11220. Through this law, Davao del Sur State College became the 112th Public Higher Education Institution in the country.

Having complied with all the requirements, the conversion of the college was approved by the Commission on Higher Education (CHED)en banc through Resolution No. 494-2019, on August 13, 2019.

On September 28, 2020, after a thorough search, the DSSC Board of Trustees approved the appointment of Dr. Augie E. Fuentes as the first president of the institution.